Drug tests for spasticity
- What are we studying?
Two drugs--amphetamine and citalopram--are being used to understand how neurons change after a spinal cord injury to produce spasticity.
- How will we do that?
After being administered the respective drug, participants will perform basic movements, like raising or lowering a foot. Small electrical impulses will be used to produce reflexes in the leg muscle, while a fine wire in the shin muscle will be used to record motor unit responses.
- Who can participate?
Adults with complete or incomplete SCI >1 year ago who have some spasticity in their legs.
- What are some potential benefits?
You will likely not receive any direct benefit from this experiment, although you may learn which anti-spastic drugs do or do not work for you. These experiments will help us understand why spasticity develops after spinal cord injury. This may help us develop better anti-spastic drugs.
- How much time does it take?
Two days for 3 to 4 hours.